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SOFTWARE
Downloadable Programs
- SPLASH: (structural pattern localization analysis by sequential histograms) is a deterministic pattern discovery algorithm which can find sparse amino or nucleic acid patterns matching identically or similarly in a set of protein or DNA sequences. Sparse patterns of any length, up to the size of the input sequence can be discovered without significant loss in performance. Splash is extremely efficient and embarrassingly parallel by nature
- geWorkbench: is a Java-based open-source platform for integrated genomics. Using a component architecture it allows individually developed plug-ins to be configured into complex bioinformatic applications. At present there are more than 30 available plug-ins supporting the visualization and analysis of gene expression and sequence data.
- ARACNE: (Algorithm for the Reconstruction of Accurate Cellular Networks), a novel algorithm, using microarray expression profiles, specifically designed to scale up to the complexity of regulatory networks in mammalian cells, yet general enough to address a wider range of network deconvolution problems. This method uses an information theoretic approach to eliminate the vast majority of indirect interactions typically inferred by pairwise analysis. Software/ARACNE
- B-Cell Interactome: The B cell interactome (BCI) is a network of protein-protein, protein-DNA and modulatory interactions in human B cells. The network contains known interactions (reported in public databases) and predicted interactions by a Bayesian evidence integration framework which integrates a variety of generic and context specific experimental clues about protein-protein and protein-DNA interactions - such as a large collection of B cell expression profiles - with inferences from different reverse engineering algorithms, such as GeneWays and ARACNE. Modulatory interactions are predicted by the MINDY, an algorithm for the prediction of modulators of transcriptional interactions (please, refer to the publication section for more information).
- Cleaner: R-system software package for the assembly of informative, transcript-specific probe-clusters for Affymetrix expression microarrays.