Synthetic Five-Gene Network Inference (DREAM2, Challenge 3)
A synthetic-biology network consisting of 5 interacting genes was created and transfected to an in-vivo model organism. The challenge consists of predicting the connectivity of the five-gene network from in-vivo measurements.
About the Data
- Data generously provided by Maria Pia Cosma and Diego di Bernardo, TIGEM Telethon Institute of Genetics and Medicine, Naples, Italy
- Reference: Cantone I, Marucci L, Iorio F, Ricci MA, Belcastro V, Bansal M, Santini S, di Bernardo M, di Bernardo D, Cosma MP. "A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches." Cell. 2009 Apr 3;137(1):172-81. PubMed
- Team 0: Alberto de la Fuente, Angela Baralla, and Wieslaws Mentzen, CRS4 Bioinformatica, Universita degli Studi di Sassari, Italy
- Team 1: Daniel Marbach, Claudio Mattiussi, and Dario Floreano, from the Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland.