Genome-Scale Network Inference (DREAM2, Challenge 5)
A panel of single-channel microarrays was collected for a particular microorganism, including some already published and some in-print data. The data was appropriately normalized (to the logarithmic scale). The challenge consists of reconstructing a genome-scale transcriptional network for this organism. The accuracy of network inference will be judged using chromatin precipitation and otherwise experimentally verified Transcription Factor (TF)-target interactions.
About the Data
- Data generously provided by Tim Gardner, Boston University
- Reference: Faith JJ, Hayete B, Thaden JT, Mogno I, Wierzbowski J, Cottarel G, Kasif S, Collins JJ, Gardner TS. Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles. PLoS Biol. 2007 Jan;5(1). PubMed
- Many Microbe Microarrays Database (M3D)
- Team 1: Dimitris Anastassiou, John Watkinson, Kuo-ching Liang, Xiadong Wang, and Tian Zheng, Columbia University.