Signaling Cascade Identification (DREAM3, Challenge 1)
The concentration of four intracellular proteins or phospho-proteins (X1, X2, X3 and X4) participating in a signaling cascade were measured in about 104 cells by antibody staining and flow cytometry. The idea of this challenge is to explore what key aspects of the dynamics and topology of interactions of a signaling cascade can be inferred from incomplete flow cytometry data.
About the Data
- Data generously provided by Gregoire Altan-Bonnet, Memorial Sloan-Kettering Cancer Center
- Reference: Feinerman O, Veiga J, Dorfman JR, Germain RN, Altan-Bonnet G. "Variability and robustness in T cell activation from regulated heterogeneity in protein levels." Science. 2008 Aug 22;321(5892):1081-4. PubMed
- There was no best performer for this challenge.