Contents |
Overview
DREAM is a Dialogue for Reverse Engineering Assessments and Methods. The main objective is to catalyze the interaction between experiment and theory in the area of cellular network inference. The fundamental question for DREAM is simple: How can researchers assess how well they are describing the networks of interacting molecules that underlie biological systems? The answer is not so simple. Researchers have used a variety of algorithms to deduce the structure of very different biological and artificial networks, and evaluated their success using various metrics. What is still needed, and what DREAM aims to achieve, is a fair comparison of the strengths and weaknesses of the methods and a clear sense of the reliability of the network models they produce.
Thrusts
The DREAM project is composed of three interrelated thrusts.
- The organization of periodic Conferences
- The organization of Reverse-Engineering Challenges
- An online venue to Discuss reverse-engineering topics and curate Data, Literature, and Methods.
Upcoming Conference and Challenges: DREAM4 (2009)
The DREAM4 Conference is in the planning stages. The conference dates will be announced soon.
Organizers
- Gustavo Stolovitzky, IBM Computational Biology Center
- Andrea Califano, Columbia University
Steering Committee
Alexander Hartemink, Andre Levchenko, Benno Schwikowski, Diego Di Bernardo, Eran Segal, Fritz Roth, Hamid Bulouri, Harmen Bussemaker, Jim Collins, Joel Bader, John Moult, Marc Vidal, Mark Gerstein, Mike Snyder, Mike Yaffee, Pedro Mendes, Ron Shamir, Tim Gardner, Trey Ideker
Sponsors
- Columbia University Center for Multiscale Analysis Genomic and Cellular Networks (MAGNet)
- NIH Roadmap Initiative
- IBM Computational Biology Center
- The New York Academy of Sciences