Intragen Population Genetics Database

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Intragen Home | Requirements | Data | Design & Development | Setup & Configuration

INTRODUCTION

The Intragen population genetics database (IntragenDB) will provide free access to genome wide SNP data for the scientific community on a variety of control populations. The SNP data has been generated using the whole-genome HumanHap300 genotyping platform from Illumina Inc.

The majority of DNA samples have been derived from a population cohort of approximately 18,000 normal subjects. The subjects enrolled in this cohort were between the ages of 30 and 60 at the time of enrollment. The age, sex and ethnicity of subjects are provided to users of the SNP database free of charge. The cohort is a population based sample of volunteer normal control subjects enrolled in the New York Health Project (formerly the New York Cancer Project), a longitudinal cohort developed for the study of cancer and other common diseases.

DATA

The data made available comprise (1) genotypic informartion on about 300,000 SNPs per DNA sample, and (2) a reduced set of associated phenotypic attributes (date of birth, gender, ethnicity. See Data section for examples genotypic and phenotypic files.

FUNCTIONALITY

In its first phase, IntragenDB will allow:

• User registration: Database access will be open only to registered users from the academia. For such users the system will support creation of accounts, issuing of credentials, authentication, account activation/deactivation.
• Data querying: Using a simple querying interface registered users will be able to select a subpopulation of interest by specifying ranges of values over the available phenotypic attributes. The system will compile datafiles containing the genotypes and phenotypes for the DNA samples in the designated subpopulation and post then in a secure area for pickup by the users.