Gene Ontology Term Analysis

Revision as of 13:54, 10 November 2009 by Smith (talk | contribs) (Overview)

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Overview

The Gene Ontology project describes genes (gene products) using terms from three structured vocabularies: biological process, cellular component and molecular function.

A number of analysis methods in geWorkbench a list of interesting genes, for example, those differentially expressed (t-test), or those which show similarities in expression (Hierarchical Clustering, SOM, ARACNe). The Gene Ontology Enrichment component, also referred to as the "GO Terms" component, allows the genes in such a list to be characterized using their assignments to various categories in the Gene Ontology. It asks, for this list of genes, are any GO categories present at a level higher than expected by chance?

Information about the several enrichment methods can be found at http://compbio.charite.de/index.php/ontologizer2.html.


This tutorial is currently being developed and will be complete on November 11, 2009.