CeRNA Query
This component provides query access to a database of competitive endogenous RNA (ceRNA) interactions, also called "sponge" interactions. These interactions are predicted using the Hermes algorithm as described in Sumazin et al. (2011) with subsequent improvements (submitted). Hermes is used to predict the intersection set of miRNAs which bind to both of two different RNAs. Variation in the level of one of the RNA species may affect the level of the second RNA via its effects on the availability of the various miRNAs, providing a regulatory mechanism for gene expression.
Sumazin P, Yang X, Chiu HS, Chung WJ, Iyer A, Llobet-Navas D, Rajbhandari P, Bansal M, Guarnieri P, Silva J, Califano A. (2011) An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell 147(2):370-81. doi: 10.1016/j.cell.2011.09.041.
