Difference between revisions of "Viper Analysis"

(Parameters)
(Parameters)
Line 11: Line 11:
  
 
* '''Select Regulon'''
 
* '''Select Regulon'''
** '''hl60_cmap2_tf_regulon''' - B-cell lymphoma, CMAP2 data
+
** '''hl60_cmap2_tf_regulon''' - Human promyelocytic leukemia, CMAP2 data
** '''mcf7_cmap2_tf_regulon''' - Breast cancer, CMAP2 data
+
** '''mcf7_cmap2_tf_regulon''' - Breast adenocarcinoma, CMAP2 data
 
** '''pc3_cmap2_tf_regulon''' - Prostate cancer, CMAP2 data
 
** '''pc3_cmap2_tf_regulon''' - Prostate cancer, CMAP2 data
  

Revision as of 14:51, 21 November 2013

Page in preparation, should be available 11/22/2013.


VIPER analysis.png

Parameters

  • Select Service
    • Local Service - run VIPER on an instance of R installed on the same machine as geWorkbench.
    • Web service - not yet implemented. Run Viper on a remote server.
  • Select Regulon
    • hl60_cmap2_tf_regulon - Human promyelocytic leukemia, CMAP2 data
    • mcf7_cmap2_tf_regulon - Breast adenocarcinoma, CMAP2 data
    • pc3_cmap2_tf_regulon - Prostate cancer, CMAP2 data
  • Select Method
    • none - no correction.
    • scale - for each gene (row in dataset), calculate the mean and standard deviation across all columns, then subtract the mean from each value in the row, and divide each by the standard deviation.
    • rank -
    • mad -
    • ttest - for each gene, perform a t-test comparing each sample (column) one-at-a-time against all other samples taken together.